CRISPR screen platform

Han, K., et al. “Genome-wide CRISPR screens in lung cancer spheroids identify 3D growth specific cancer vulnerabilities.” Nature, 580(7801), 136-141 (2020)

Han, K., Jeng, E.E., Hess, G.T., Morgens, D.W., Li, A. and Bassik, M.C., “Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.” Nature biotechnology35(5), 463 (2017)

3D spheroids culture platform

Lee, H., Stowers, R., and Chaudhuri, O. “Volume expansion and TRPV4 activation regulate stem cell fate in three dimensional microenvironments.” Nature communication 10, 529 (2019)

Lee, H., Gu, L., Mooney, D. J. Levenston, E. M., and Chaudhuri, O. “Mechanical confinement regulates cartilage matrix formation by chondrocytes.” Nature materials 16(12), 1243 (2017)

Chaudhuri, O., Gu, L., Klumpers, D, Darnell, M., Bencherif, S. A., Weaver, J. C., Huebsch, N., Lee, H., Lippens, E., Duda G. N., and Mooney, D. J. “Hydrogels with tunable stress relaxation properties to regulate stem cell fate and activity.” Nature materials 15 (3), 326 (2016)

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